Prophylactic antibiotics

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General about prophylactic antibiotics

Statement about Antibiotic prophylaxis before dental procedures

Antibiotics in bone cement

 

 

1 General remarks about prophylactic antibiotics

The use of prophylactic antibiotics is today the most effective measure how to protect patients with artificial joints against postoperative infection, early or late.

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The prophylactic antibiotics must be in place already before the bacteria land in the wound. For prevention of the postoperative infection, the antibiotics are usually injected some 30 minutes before the start of the operation.  In this way the levels of the antibiotic in the blood will attain concentrations that will kill occasional bacteria that may land in the operation wound.

Antibiotics applied after the bacteria get hold on the surface of the artificial joint and produced a protective slime envelope are without effect.

Studies demonstrated that for  prophylaxis against postoperative wound infection, administering antibiotics during only one day after the operation has been equally effective as a two day or longer antibiotic prophylactic regime.

For occasions later on, when you need antibiotic protection during dental surgery and like, usually one dose of antibiotics before the dental and other surgery is sufficient. Ask your surgeon for detailed instructions.

There are also risks connected with the use of antibiotics. One is the development of antibiotic-resistant bacterial strains, another  is the development of an allergy to antibiotics.

You can diminish these risks yourself: use the antibiotics only when really necessary, and then use them only during the shortest interval possible.


 

2 Statement about prophylactic antibiotic before dental procedures

In 2003 the American Dental Association and American Academy of Ortopaedic Surgeons issued a common statement about the use of prophylactic antibiotics before common dental procedures. These guidelines were usually followed by the most doctors, more because of fear of litigation than because a proven connection between dental procedures and infection of total joints.

Here follows this Statement. Don't forget that it applies on dental procedures on non-infected teeth only. All infections in the mouth and on teeth must be treated  vigorously with correct use of antibiotics.

J Am Dent Assoc, 2003 Vol 134,  899.

Your joint replacement, dental procedures and antibiotics
by: American Dental Association, and American Academy of Orthopaedic Surgeons

For the first two years after a joint replacement, all patients may need antibiotics for all high-risk dental procedures. After two years, only high-risk patients may need to receive antibiotics for high-risk procedures.

The bacteria commonly found in the mouth may travel through the bloodstream and settle in your artificial joint. This increases your risk of contracting an infection. Ask your dentist about preventive antibiotics for all dental procedures with a high risk of bleeding or producing high levels of bacteria in your blood. Your dentist and your orthopaedic surgeon, working together, will develop an appropriate course of treatment for you.

You may need preventive antibiotics before all high-risk dental procedures if

you had a joint replacement less than two years ago.

you’ve had previous infections in your artificial joint.

you have an inflammatory type of arthritis, type 1 diabetes or hemophilia.

you have a suppressed immune system or are malnourished.

you have a history of prior or present malignancy.

These dental procedures have a high risk of bleeding or producing high levels of bacteria in your blood:

all dental extractions;

all periodontal procedures;

dental implant placement and replantation of teeth that were knocked out;

some root canal work;

initial placement of orthodontic bands (not brackets);

certain specialized local anesthetic injections;

regular dental cleanings (if bleeding is anticipated).

One of these preventive antibiotics may be prescribed for you:

if you are not allergic to penicillin: 2 grams of amoxicillin, cephalexin or cephradine (orally) OR 2 grams of ampicillin or 1 gram of cefazolin (intramuscularly or intravenously) 1 hour before the procedure.

if you are allergic to penicillin: 600 milligrams of clindamycin (orally or intravenously) 1 hour before the procedure.

These guidelines were developed by the American Academy of Orthopaedic Surgeons and the American Dental Association. They are designed to help practitioners make decisions about preventive antibiotics for dental patients with artificial joints. They are not a standard of care or a substitute for the practitioner’s clinical judgment. Practitioners must exercise their own clinical judgment in determining whether or not preventive antibiotics are appropriate. Pediatric doses may be different.

 


3  Antibiotics in bone cement

under preparation (Parvizi et al. Acta Orthoped 2008, 79, 335 - 42.